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KMID : 0364820230590020061
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Korean Journal of Microbiology
2023 Volume.59 No. 2 p.61 ~ p.68
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Estimating toxic equivalent factors for microcystin congeners using protein phosphatase inhibition assay
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Lee Jae-Hun
Shin Yu-Na
Cho Young-Cheol
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Abstract
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The guidelines for microcystins (MCs), which are cyanobacterial toxin, in drinking water or recreational water do not reflect the difference in the toxicity of MC congeners. In this study, the toxicity equivalent factors (TEFs) of four types of MC congeners, widely found in freshwater environments, were estimated based on the relative extent of enzyme inhibition using the protein phosphatase inhibition assay. The TEFs of MC-RR, MC-YR, and MC-LA to MC-LR were 0.149, 0.257, and 0.392, respectively.
Based on these results, we presented an equation for converting the concentration of four MC congeners measured from environmental samples into toxic equivalent quantity for MC-LR (TEQMC-LR). Practical and efficient risk management for MC congeners is possible if the guidelines are established based on TEQMC-LR by applying the TEF for the four MC congeners presented in this study.
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KEYWORD
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congener, guidelines, microcystins, protein phosphatase inhibition assay, toxicity equivalent factor
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